Research Investigators

Photo Principal Investigator Institution	Research Interests
Kristin Artinger, Ph.D. University of Colorado Denver	zebrafish, embryogenesis, patterning, neural development
Anil Bhushan, Ph.D. University of California, Los Angeles	beta cell regeneration, cell cycle regulation, embryogenesis
John Buse, M.D. The University of North Carolina at Chapel Hill	Primary interest: large-scale multi-center trials focused on prevention and treatment of diabetes and its complications. Secondary interest: collaborative research (T1 translation) in diabetes
Howard Cedar, M.D. Hebrew University	DNA methylation, DNA replication, epigenetics, genome, transgenic mouse models, chromatin structure, gene expression
Chin-Tu Chen, Ph.D. University of Chicago	molecular imaging, PET, SPECT, optical imaging
Ondine Cleaver, Ph.D. UT Southwestern Medical Center	Developmental biology, organogenesis, angiogenesis/vasculogenesis, stem cell differentiation
George Daley, M.D., Ph.D. Harvard Medical School
Philip Joseph DiIorio, Ph.D. University of Massachusetts Medical School	Diabetes; embryo; development; beta cell; insulin
Yuval Dor Hebrew University-Hadassah Medical School, Ein Kerem	Tissue dynamics, Organ size control, Stem cells, Pancreas development, Beta cell regeneration
Richard H. Goodman Oregon Health & Science University	Intracellular signals
Gerard Gradwohl, Ph.D Institute of Genetics and Molecular and Cellular Biology (IGBMC)	Genetic control of pancreatic and intestinal endocrine cells differentiation
Anne Grapin-Botton EPFL	Mechanisms of organ formation in the endoderm. Endocrine cell development.
Dale L Greiner, Ph.D. University of Massachusetts Medical School	autoimmune diabetes, Transplantation tolerance, beta cell regeneration, humanized mice
Markus Grompe Oregon Health & Science University	metabolic liver diseases, molecular genetics of Fanconi Anemia, hepatic and pancreatic stem cells
Guoqiang Gu, Ph.D. Vanderbilt University	Endocirne islet cell differentiation and functional maintenance, adult pancreatic progenitor during regeneration, cell marking and cell lineage
Manami Hara, Ph.D. The University of Chicago
Harry Heimberg Vrije Universiteit Brussels	The biology of the pancreatic (pre)beta-cell. Recombinant adeno- and lentivirus construction to analyze differential gene expression.
Pedro Luis Herrera, Ph.D. University of Geneva Medical School	pancreas development; beta cell development and generation
Klaus H. Kaestner, Ph.D. University of Pennsylvania	Transcriptional Regulation of Pancreas, Liver and Gut Development in Mammals, Microarray, Transgenic Models
Gregory Karczmar, Ph.D. The University of Chicago
Gordon Keller, Ph.D. McEwen Centre for Regenerative Medicine/University Health Network	embryonic hematopoietic and vascular systems
Eugene Kolker, Ph.D. Seattle Children's Research Institute	Computational Biology, Systems Biology, Data Analysis & Integration, Proteomics, Health Informatics
Teresa Ku, Ph.D. Beckman Research Institute of the City of Hope	Committing ES Cells to Pancreatic Cells; Purification and In Vitro Expansion of Pancreatic Beta-cell Progenitors.
Ray MacDonald, Ph.D. University of Texas Southwestern	pancreatic gene transcription, transcriptional control of organogenesis, pancreatic development
Ole D. Madsen Hagedorn Research Institute	Our main focus with the BCBC is to generate novel antibody tools for important factors/markers for the different stages of pancreatic maturation. Such reagents will be made available through the Antibody Core.
Rene Maehr, Ph.D. Harvard University	autoimmune diabetes, pluripotent stem cells, directed differentiation, disease modeling
Mark A Magnuson, M.D. Vanderbilt University	Pancreas Development, Mouse Models, Genetic Engineering of Mouse ES Cells, Insulin Secretion
Melissa Mahoney, Ph.D. University of Colorado
Ahmed Mansouri, PhD Max-Planck Institute	mouse ES cells, endocrine pancreas, Parkinson disease, Midbrain development, in vitro differentiation of ES cells
Doug Melton, Ph.D. Harvard / HHMI	Microarray, Mouse/Human Stem Cell, Embryonic Development, Islet Cells, Pancreas Development
Charles Murtaugh, Ph.D. University of Utah	Notch, Wnt, lineage-tracing, metaplasia, mouse
Todd Peterson, Ph.D. Vanderbilt University	Molecular Imaging
Louis Philipson, M.D. University of Chicago	see: http://www.kovlerdiabetescenter.org/ http://diabetes.bsd.uchicago.edu http://drtc.bsd.uchicago.edu
Alvin Powers, M.D. Vanderbilt University	diabetes, islet function, islet transplantation, vascularization
Brian Bernard Roman, Ph.D. university of chicago	MRI Beta cell function Islet transplantation
Maike Sander, M.D. University of California at San Diego	Genetic control of pancreatic cell differentiation, using mouse as a model system.
Raphael Scharfmann INSERM	Diabetes
Stephan Schneider, M.D. University Hospital Bergmannsheil	PET, SPECT, beta cell mass, imaging, bioluminscence, radioligands
Henrik Semb, Ph.D Lund University	pancreas development, human embryonic stem cells, beta cell differentiation, morphogenesis, epithelial-mesenchymal interactions, cell adhesion, cell migration, blood vessels
Palle Serup Hagedorn Research Institute	Pancreatic development. Promoter and transcription factor analyses.
Ming Chi Shih, MD, PhD University of Chicago	Molecular In Vivo Imaging, Receptor Imaging, Dopamine Transporter Imaging, Neurosciences
Leonard D Shultz The Jackson Laboratory	Humanized mouse model for studying diabetes, bone development, autoimmunity
Didier Stainier University of California, San Francisco	The Stainier lab is taking a genetic approach in zebrafish to study vertebrate endoderm, heart and blood vessel formation and function. We are working with several mutations that affect distinct aspects of endodermal and/or cardiovascular development.
Ben Stanger, M.D. University of Pennsylvania	Organogenesis, Development, Notch, Size Regulation, Morphogenesis
Roland W. Stein, Ph.D. Vanderbilt University	Control of insulin gene transcription and islet development
Andrew F. Stewart University of Pittsburgh	Cell Cycle Control Himan Beta Cell
Christian Stoeckert, Ph.D. University of Pennsylvania	Bioinformatics
Philip R Streeter, Ph.D. Oregon Health & Science University
Lori Sussel, Ph.D. Columbia University	Genetic Differentiation of Endocrine Pancreatic Cells
Bjoern Waengler University of Munich (LMU)
Chris Wright, Ph.D. Vanderbilt University	Molecular embryology/vertebrate embryogenesis/transcription factors/intercellular signaling
Peter W Zandstra, PhD University of Toronto
Kenneth S. Zaret, Ph.D. University of Pennsylvania School of Medicine	specification of pancreatic progenitors, endocrine progenitors, beta cells cell signaling, chromatin, and transcriptional mechanisms
Yi Zhang, Ph.D. The University of North Carolina at Chapel Hill/Howard Hughes Medical Institute	Epigenetics, reprogramming, stem cells, iPS cells, chromatin, transcription, islet transplantation, transdifferentiation