Research Investigators

Principal Investigator	Research Interests
Per-Olof Berggren Karolinska University BCBC Co-investigator
Anil Bhushan, Ph.D. University of California, Los Angeles BCBC Investigator	beta cell regeneration, cell cycle regulation, embryogenesis
Howard Chang, M.D. Ph.D Stanford University BCBC Investigator	gene regulation, lincRNA, chromatin, genomics
Peter Dervan, Ph.D California Institute of Technology BCBC Co-investigator
Philip DiIorio, Ph.D. University of Massachusetts Medical School BCBC Co-investigator	Diabetes; embryo; development; beta cell; insulin
Yuval Dor, PhD Hebrew University-Hadassah Medical School, Ein Kerem BCBC Co-investigator	Tissue dynamics, Organ size control, Stem cells, Pancreas development, Beta cell regeneration
Hans-Peter Elsaesser, Ph.D. Philipps-Universität Marburg BCBC Co-investigator	sking agin, regulation of autophagy in higher eukaryotic cells, function of the Myc-binding protein Miz1 in keratinocytes and in cells of the mammary gland
Jorge Ferrer, M.D., Ph.D. Hospital Clinic de Barcelona BCBC Investigator	Transcrpitonal regulation of pancreatic beta cells, pancreas regeneration, genetic mechanisms of diabetes
Paul Gadue Children's Hospital of Philadelphia BCBC Co-investigator	ES cells, iPS cells, In vitro differentiation
Maureen Gannon, Ph.D. Vanderbilt University Medical Center BCBC Investigator	beta cell mass regulation, pancreas development, cell fate regulation, progenitor cells, gestational diabetes
Adolfo Garcia-Ocana, PhD University of Pittsburgh BCBC Co-investigator	Beta cell, proliferation, apoptosis, growth factor, signaling pathway, HGF, PKC, mTOR.
Mike German, M.D. University of California, San Francisco BCBC Investigator	Pancreatic Beta Cell
David Gifford, Ph.D Massachusetts Institute of Technology BCBC Co-investigator
Benjamin Glaser Hadassah-Hebrew University Medical Center BCBC Co-investigator
Gerard Gradwohl, Ph.D Institute of Genetics and Molecular and Cellular Biology (IGBMC) BCBC Investigator	Genetic control of pancreatic and intestinal endocrine cells differentiation
Anne Grapin-Botton, Ph.D. EPFL BCBC Investigator	Mechanisms of organ formation in the endoderm, Endocrine cell development, planar cell polarity, beta cell, architecture, polarity, Wnt pathway.
Dale Greiner, Ph.D. University of Massachusetts Medical School BCBC Investigator	autoimmune diabetes, Transplantation tolerance, beta cell regeneration, humanized mice
Markus Grompe, M.D. Oregon Health & Science University BCBC Investigator	metabolic liver diseases, molecular genetics of Fanconi Anemia, hepatic and pancreatic stem cells
Guoqiang Gu, Ph.D. Vanderbilt University BCBC Investigator	Endocirne islet cell differentiation and functional maintenance, adult pancreatic progenitor during regeneration, cell marking and cell lineage
Manami Hara, Ph.D. The University of Chicago BCBC Co-investigator
David Harlan, MD University of Massachusetts BCBC Investigator	Pathogenesis of type 1 diabetes mellitus, rejection organs/tissues transplanted with diabetes, exploring beta cell biology
Matthias Hebrok, Ph.D. University of California, San Francisco BCBC Investigator	Pancreas Islet Development
Harry Heimberg, Ph.D. Vrije Universiteit Brussels BCBC Investigator	Biology of the pancreatic (pre)beta-cell.
Pedro Herrera, Ph.D. University of Geneva Faculty of Medicine BCBC Investigator	pancreas development; beta cell development and generation; regeneration; reprogramming; cell tracing; transgenic mice
Klaus Kaestner, Ph.D. University of Pennsylvania BCBC Investigator	Epigenomics of beta-cells; beta-cell proliferation; transcriptional regulation of pancreas development
Jeffrey Karp, B.Eng., Ph.D. Brigham and Women's Hospital BCBC Co-investigator	stem cell bioengineering, medical adhesives, diagnostic devices, medical devices, drug delivery, controlled release, sensors, nanotechnology, mesenchymal stem cell biology, cell trafficking, cell homing.
Mark Kay, M.D., Ph.D Stanford University BCBC Investigator	gene transfer, gene therapy, viral vectors, non-viral vectors, small RNAs, MicroRNAs, RNA interference, hemophilia, diabetes, hepatitis
Gordon Keller, Ph.D. McEwen Centre for Regenerative Medicine/University Health Network BCBC Investigator	embryonic hematopoietic and vascular systems
Seung Kim, M.D., Ph.D. Stanford University School of Medicine/HHMI BCBC Investigator	Pancreas developmental biology, diabetes, islet biology, genetics, epigenetics
Eugene Kolker, Ph.D. Seattle Children's Research Institute BCBC Investigator	Computational Biology, Systems Biology, Data Analysis & Integration, Proteomics, Health Informatics
Teresa Ku, Ph.D. Beckman Research Institute of the City of Hope BCBC Co-investigator	Committing ES Cells to Pancreatic Cells; Purification and In Vitro Expansion of Pancreatic Beta-cell Progenitors.
Jake Kushner, M.D. Baylor College of Medicine BCBC Co-investigator	Beta cell regeneration, beta-cell survival.
Rudy Leibel Columbia University BCBC Co-investigator
Charles Lin, Ph.D Massachusetts General Hospital BCBC Co-investigator
Ray MacDonald, Ph.D. University of Texas Southwestern BCBC Investigator	pancreatic gene transcription, transcriptional control of organogenesis, pancreatic development
Ole Madsen, Ph.D. Hagedorn Research Institute BCBC Investigator	antibody, cell surface, epitope, extracellular, cell lineage tracing, fluorescent cells, antibody tags, cell sorting, cell separation, cell culture, antibody mediated cell purification, protocol development.
Mark Magnuson, M.D. Vanderbilt University BCBC Investigator	Pancreas Development, Mouse Models, Next Generation Sequencing, Cell Reprogramming
Melissa Mahoney, Ph.D. University of Colorado BCBC Co-investigator
Doug Melton, Ph.D. Harvard / HHMI BCBC Investigator	Microarray, Mouse/Human Stem Cell, Embryonic Development, Islet Cells, Pancreas Development
Stephen Miller, Ph.D. Northwestern University BCBC Co-investigator	Immunoregulation, autoimmune disease, type 1 diabetes, mulitple sclerosis,experimental autoimmune encephalomyelitis, transplantation, tolerance, costimulatory molecule blockade
Anna Moore, Ph.D. Masachusetts General Hospital BCBC Co-investigator	Molecular imaging, image-guided therapy, contrast agent, non-invasive monitoring of drug distribution
Ferenc Mueller University of Birmingham BCBC Co-investigator
Chris Newgard, Ph.D. Duke University Medical Center BCBC Investigator	metabolic regulatory mechanisms
Feroz Papa, M.D., Ph.D. University of California San Francisco BCBC Investigator	apoptosis, stress signaling, endoplasmic reticulum, beta cells, insulin
Alvin Powers, M.D. Vanderbilt University BCBC Investigator	diabetes, islet function, islet transplantation, vascularization
Philippe Ravassard, PhD CNRS – UMR 7225 BCBC Co-investigator	Pancreas development, beta cells, gene tranfer, lentiviral vectors
Bing Ren, Ph.D. University of California San Diego BCBC Co-investigator
Arthur Riggs, Ph.D City of Hope BCBC Investigator	Epigenetics
Derrick Rossi, Ph.D. Immune Disease Institute BCBC Co-investigator	hematopoietic stem cells, reprogramming, modified-mRNA
Maike Sander, M.D. University of California at San Diego BCBC Investigator	Genetic control of pancreatic cell differentiation, using mouse as a model system.
Raphael Scharfmann, Ph.D. INSERM BCBC Investigator	Pancreas, beta cells, diabetes, development
Donald Scott, PhD University of pittsburgh BCBC Co-investigator
Michael Sefton, Sc.D. University of Toronto BCBC Co-investigator	biomaterials, tissue engineering, angiogenesis, endothelial cells
Henrik Semb, Ph.D Lund University BCBC Investigator	pancreas development, human embryonic stem cells, beta cell differentiation, morphogenesis, epithelial-mesenchymal interactions, cell adhesion, cell migration, blood vessels
David Serreze, BS, MS, PhD The Jackson Laboratory BCBC Co-investigator	type I diabetes, autoimmunity, mouse models, immune therapy
Ehud Shapiro Weizmann Institute of Science, Israel BCBC Co-investigator
Leonard Shultz, Ph.D. The Jackson Laboratory BCBC Investigator	Humanized mouse model for studying diabetes, bone development, autoimmunity
Michael Snyder, Ph.D Stanford University BCBC Investigator	Genomics, Proteomics, Chip-Seq, RNA-Seq, Variation, Sequencing
Didier Stainier, Ph.D. University of California, San Francisco BCBC Investigator	The Stainier lab studies pancreatic beta-cell development and regeneration in zebrafish
Roland Stein, Ph.D. Vanderbilt University BCBC Investigator	Control of islet beta cell development and function
Andrew Stewart, M.D. University of Pittsburgh BCBC Investigator	Cell Cycle Control Human Beta Cell
Christian Stoeckert, Ph.D. University of Pennsylvania BCBC Investigator	Bioinformatics, networks, gene regulation
Doris Stoffers, M.D., Ph.D. University of Pennsylvania School of Medicine BCBC Investigator	diabetes, insulin, beta cell, pancreas development, transcriptional regulation, signal transduction
Philip Streeter, Ph.D. Oregon Health & Science University BCBC Investigator	Tissue engineering, tissue repair, lung progenitor cells, pancreatic cancer
Lori Sussel, Ph.D. Columbia University BCBC Investigator	Genetic Differentiation of Endocrine Pancreatic Cells
David Tirrell, Ph.D California Institute of Technology BCBC Co-investigator
Rupangi Vasavada, Ph.D. University of Pittsburgh - School of Medicine BCBC Co-investigator	Pancreatic beta cell, growth factors, lactogens, parathyroid-hormone-related peptide, apoptosis, proliferation, regeneration, signaling, diabetes, islet transplants, human beta cell.
James Wells, PhD Cincinnati Children's Hospital Medical Center BCBC Co-investigator	Endoderm organogenesis, human pluripotent stem cells, endocrine cell development, metabolic disease, Diabetes
Karl Willert, Ph.D University of California, San Diego BCBC Investigator	Cell signaling, Cellular Microarray Technology, Extracellular Microenvironment, Human Pluripotent Stem Cells, Microarray, Stem Cells, Wnt, Wnt Signaling
Chris Wright, Ph.D. Vanderbilt University BCBC Investigator	Molecular embryology, vertebrate embryogenesis, transcription factors, intercellular signaling, stem cells
Mervin Yoder, M.D. Indiana University BCBC Investigator	stem cells, B1 B cell, progenitor cells, angiogenesis
Peter Zandstra, PhD University of Toronto BCBC Investigator	Stem Cell Bioengineering, Regenerative Medicine, Cellular Engineering, Biprocess Engineering, Population Dynamics, Signaling Dynamics, Pluripotent (P) Stem Cells, Embryonic (E) Stem Cells, Cellular Systems Biology
Kenneth Zaret, Ph.D. University of Pennsylvania School of Medicine BCBC Investigator	specification of pancreatic progenitors, endocrine progenitors, beta cells, cell signaling, chromatin, and transcriptional mechanisms
Yi Zhang, Ph.D. The University of North Carolina at Chapel Hill/Howard Hughes Medical Institute BCBC Investigator	Epigenetics, reprogramming, stem cells, iPS cells, chromatin, transcription, islet transplantation, transdifferentiation
Qiao Zhou, Ph.D. Harvard University BCBC Investigator	regeneration, beta cells, in vivo reprogramming, diabetes