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Research Investigators

Principal Investigator BCBC Role Research Interests
Per-Olof Berggren
Karolinska University
BCBC Co-investigator
Anil Bhushan, Ph.D.
University of California, Los Angeles
BCBC Investigator

beta cell regeneration, cell cycle regulation, embryogenesis

Howard Chang, M.D. Ph.D
Stanford University
BCBC Investigator

gene regulation, lincRNA, chromatin, genomics

Philip DiIorio, Ph.D.
University of Massachusetts Medical School
BCBC Co-investigator

Diabetes; embryo; development; beta cell; insulin

Yuval Dor, PhD
Hebrew University-Hadassah Medical School, Ein Kerem
BCBC Co-investigator

Tissue dynamics, Organ size control, Stem cells, Pancreas development, Beta cell regeneration

Hans-Peter Elsaesser, Ph.D.
Philipps-Universität Marburg
BCBC Co-investigator

sking agin, regulation of autophagy in higher eukaryotic cells, function of the Myc-binding protein Miz1 in keratinocytes and in cells of the mammary gland

Jorge Ferrer, M.D., Ph.D.
Imperial College London
BCBC Investigator

Genomic and epigenetic regulation of pancreatic beta cells, pancreas regeneration, genetic mechanisms of diabetes

Paul Gadue, Ph.D.
Children's Hospital of Philadelphia
BCBC Co-investigator

ES cells, iPS cells, In vitro differentiation

Maureen Gannon, Ph.D.
Vanderbilt University Medical Center
BCBC Investigator

beta cell mass regulation, pancreas development, cell fate regulation, progenitor cells, gestational diabetes

Adolfo Garcia-Ocana, PhD
Icahn School of Medicine at Mount Sinai
BCBC Co-investigator

Beta cell, proliferation, apoptosis, growth factor, signaling pathway, HGF, PKC, mTOR.

Mike German, M.D.
University of California, San Francisco
BCBC Investigator

Pancreatic Beta Cell

David Gifford, Ph.D
Massachusetts Institute of Technology
BCBC Co-investigator

computational biology, computational genomics, genomics,

Benjamin Glaser, M.D.
Hadassah-Hebrew University Medical Center
BCBC Co-investigator

Monogenic beta-cell disease, Genetics of Type 2 Diabetes, Beta-cell survival,  Beta-cell replication

Anne Grapin-Botton, Ph.D.
DanStem, Univeristy of Copenhagen
BCBC Investigator

Mechanisms of organ formation in the endoderm, Endocrine cell development, planar cell polarity,  beta cell, architecture, polarity, Wnt pathway.

Dale Greiner, Ph.D.
University of Massachusetts Medical School
BCBC Investigator

autoimmune diabetes, Transplantation tolerance, beta cell regeneration, humanized mice

Markus Grompe, M.D.
Oregon Health & Science University
BCBC Investigator

metabolic liver diseases, molecular genetics of Fanconi Anemia, hepatic and pancreatic stem cells

Guoqiang Gu, Ph.D.
Vanderbilt University
BCBC Investigator

Endocirne islet cell differentiation and functional maintenance, adult pancreatic progenitor during regeneration, cell marking and cell lineage, beta cell stress, biomarkers, beta cell death, insulin vesicular traffic, insulin secretion, microtubules, insulin secretion repression.

Manami Hara, D.D.S., Ph.D.
The University of Chicago
BCBC Co-investigator

beta cell, islet, islet formation, pathology of the pancreas

David Harlan, MD
University of Massachusetts
BCBC Investigator

Pathogenesis of type 1 diabetes mellitus, rejection organs/tissues transplanted with diabetes, exploring beta cell biology

Matthias Hebrok, PhD
University of California, San Francisco
BCBC Investigator

Pancreas Islet Development

Harry Heimberg, Ph.D.
Vrije Universiteit Brussels
BCBC Investigator

Biology of the pancreatic (pre)beta-cell.

Pedro Herrera, Ph.D.
University of Geneva Faculty of Medicine
BCBC Investigator

pancreas development; beta cell development and generation; regeneration; reprogramming; cell tracing; transgenic mice

Klaus Kaestner, Ph.D.
University of Pennsylvania
BCBC Investigator

Epigenomics of beta-cells; beta-cell proliferation; transcriptional regulation of pancreas development

Jeffrey Karp, B.Eng., Ph.D.
Brigham and Women''s Hospital
BCBC Co-investigator

stem cell bioengineering, medical adhesives, diagnostic devices, medical devices, drug delivery, controlled release, sensors, nanotechnology, mesenchymal stem cell biology, cell trafficking, cell homing. 

Mark Kay, M.D., Ph.D
Stanford University
BCBC Investigator

gene transfer, gene therapy, viral vectors, non-viral vectors, small RNAs, MicroRNAs, RNA interference, hemophilia, diabetes, hepatitis

Gordon Keller, Ph.D.
McEwen Centre for Regenerative Medicine/University Health Network
BCBC Investigator

embryonic hematopoietic and vascular systems

Seung Kim, M.D., Ph.D.
Stanford University School of Medicine/HHMI
BCBC Investigator

Pancreas developmental biology, diabetes, islet biology, genetics, epigenetics

Eugene Kolker, Ph.D.
Seattle Children''s Research Institute
BCBC Co-investigator

Computational Biology, Systems Biology, Data Analysis & Integration,

Proteomics, Health Informatics

Rudy Leibel
Columbia University
BCBC Co-investigator
Charles Lin, Ph.D
Massachusetts General Hospital
BCBC Co-investigator

imaging, cell tracking, intravital microscopy

Ray MacDonald, Ph.D.
University of Texas Southwestern Medical Center
BCBC Investigator

transcriptional control of organogenesis, pancreatic development, beta-cell birth, acinar-to-beta cell reprogramming

Ole Madsen, Ph.D.
Hagedorn Research Institute
BCBC Investigator

antibody, cell surface, epitope, extracellular, cell lineage tracing, fluorescent cells, antibody tags, cell sorting, cell separation, cell culture, antibody mediated cell purification, protocol development.

Mark Magnuson, M.D.
Vanderbilt University
BCBC Investigator

Pancreas Development, Mouse Models, Next Generation Sequencing, Cell Reprogramming

Melissa Mahoney, Ph.D.
University of Colorado
BCBC Co-investigator
Doug Melton, Ph.D.
Harvard / HHMI
BCBC Investigator

Microarray, Mouse/Human Stem Cell, Embryonic Development, Islet Cells, Pancreas Development

Stephen Miller, Ph.D.
Northwestern University
BCBC Co-investigator

Immunoregulation, autoimmune disease, type 1 diabetes, mulitple sclerosis,experimental autoimmune encephalomyelitis, transplantation, tolerance, costimulatory molecule blockade

Anna Moore, Ph.D.
Masachusetts General Hospital
BCBC Co-investigator

Molecular imaging, image-guided therapy, contrast agent, non-invasive monitoring of drug distribution

Chris Newgard, Ph.D.
Duke University Medical Center
BCBC Investigator

metabolic regulatory mechanisms

Feroz Papa, M.D., Ph.D.
University of California San Francisco
BCBC Investigator

apoptosis, stress signaling, endoplasmic reticulum, beta cells, insulin

Alvin Powers, M.D.
Vanderbilt University
BCBC Investigator

diabetes, islet function, islet transplantation, vascularization

Philippe Ravassard, PhD
CNRS – UMR 7225
BCBC Co-investigator

Pancreas development, beta cells, gene tranfer, lentiviral vectors

Bing Ren, Ph.D.
University of California San Diego
BCBC Co-investigator

Epigenetics, Epigenome, ENCODE, gene regulation, embryonic stem cells

Maike Sander, M.D.
University of California, San Diego
BCBC Investigator

Genetic control of pancreatic cell differentiation, using mouse and human embryonic stem cells as model systems.

Donald Scott, PhD
University of pittsburgh
BCBC Co-investigator
Henrik Semb, Ph.D
Copenhagen University
BCBC Investigator

pancreas development, human embryonic stem cells, beta cell differentiation, morphogenesis, epithelial-mesenchymal interactions, cell adhesion, cell migration, blood vessels

David Serreze, BS, MS, PhD
The Jackson Laboratory
BCBC Co-investigator

type I diabetes,  autoimmunity, mouse models, immune therapy

Leonard Shultz, Ph.D.
The Jackson Laboratory
BCBC Investigator

Humanized mouse model for studying diabetes, bone development, autoimmunity

Michael Snyder, Ph.D
Stanford University
BCBC Investigator

Genomics, Proteomics, Chip-Seq, RNA-Seq, Variation, Sequencing

Didier Stainier, Ph.D.
Max Planck Institute for Heart and Lung Research
BCBC Investigator

The Stainier lab studies pancreatic beta-cell development and regeneration in zebrafish

Roland Stein, Ph.D.
Vanderbilt University
BCBC Investigator

Control of islet beta cell development and function

Andrew Stewart, M.D.
Mount Sinai School of Medicine
BCBC Investigator

Cell Cycle Control

Human Beta Cells

Christian Stoeckert, Ph.D.
University of Pennsylvania
BCBC Investigator

Bioinformatics, networks, gene regulation

Doris Stoffers, M.D., Ph.D.
Perelman School of Medicine at the University of Pennsylvania
BCBC Investigator

diabetes, insulin, beta cell, pancreas development, transcriptional regulation, signal transduction

Philip Streeter, Ph.D.
Oregon Health & Science University
BCBC Investigator

Tissue engineering, tissue repair, lung progenitor cells, pancreatic cancer

Lori Sussel, Ph.D.
Columbia University
BCBC Investigator

Genetic Differentiation of Endocrine Pancreatic Cells

Rupangi Vasavada, Ph.D.
Icahn School of Medicine at Mount Sinai
BCBC Co-investigator

Pancreatic beta cell, growth factors, lactogens, parathyroid-hormone-related peptide, apoptosis, proliferation, regeneration, signaling, diabetes, islet transplants, human beta cell.

James Wells, PhD
Cincinnati Children''s Hospital Medical Center
BCBC Co-investigator

Endoderm organogenesis, human pluripotent stem cells, endocrine cell development, metabolic disease, Diabetes

Karl Willert, Ph.D
University of California, San Diego
BCBC Investigator

Cell signaling, Cellular Microarray Technology, Extracellular Microenvironment, Human Pluripotent Stem Cells, Microarray, Stem Cells, Wnt, Wnt Signaling

Chris Wright, D. Phil.
Vanderbilt University
BCBC Investigator

Molecular embryology, vertebrate embryogenesis, transcription factors, intercellular signaling, stem cells

Mervin Yoder, M.D.
Indiana University
BCBC Investigator

stem cells, B1 B cell, progenitor cells, angiogenesis

Peter Zandstra, PhD
University of Toronto
BCBC Investigator

Stem Cell Bioengineering, Regenerative Medicine, Cellular Engineering, Biprocess Engineering, Population Dynamics, Signaling Dynamics, Pluripotent (P) Stem Cells, Embryonic (E) Stem Cells, Cellular Systems Biology

Yi Zhang, Ph.D.
Harvard Medical School & Boston Children''s Hospital
BCBC Investigator

Epigenetics, reprogramming, stem cells, iPS cells, chromatin, transcription, islet transplantation, transdifferentiation

Qiao Zhou, Ph.D.
Harvard University
BCBC Investigator

regeneration, beta cells, direct lineage reprogramming, diabetes