Research Investigators

Principal Investigator	BCBC Role	Research Interests
Per-Olof Berggren Karolinska University	BCBC Co-investigator
Anil Bhushan, Ph.D. University of California, Los Angeles	BCBC Investigator	beta cell regeneration, cell cycle regulation, embryogenesis
Howard Chang, M.D. Ph.D Stanford University	BCBC Investigator	gene regulation, lincRNA, chromatin, genomics
Philip DiIorio, Ph.D. University of Massachusetts Medical School	BCBC Co-investigator	Diabetes; embryo; development; beta cell; insulin
Hans-Peter Elsaesser, Ph.D. Philipps-Universität Marburg	BCBC Co-investigator	sking agin, regulation of autophagy in higher eukaryotic cells, function of the Myc-binding protein Miz1 in keratinocytes and in cells of the mammary gland
Jorge Ferrer, M.D., Ph.D. Imperial College London	BCBC Investigator	Genomic and epigenetic regulation of pancreatic beta cells, pancreas regeneration, genetic mechanisms of diabetes
Paul Gadue, Ph.D. Children''s Hospital of Philadelphia	BCBC Co-investigator	ES cells, iPS cells, In vitro differentiation
Maureen Gannon, Ph.D. Vanderbilt University Medical Center	BCBC Investigator	beta cell mass regulation, pancreas development, cell fate regulation, progenitor cells, gestational diabetes
Adolfo Garcia-Ocana, PhD Icahn School of Medicine at Mount Sinai	BCBC Co-investigator	Beta cell, proliferation, apoptosis, growth factor, signaling pathway, HGF, PKC, mTOR.
Mike German, M.D. University of California, San Francisco	BCBC Investigator	Pancreatic Beta Cell
David Gifford, Ph.D Massachusetts Institute of Technology	BCBC Co-investigator	computational biology, computational genomics, genomics,
Benjamin Glaser, M.D. Hadassah-Hebrew University Medical Center	BCBC Co-investigator	Monogenic beta-cell disease, Genetics of Type 2 Diabetes, Beta-cell survival, Beta-cell replication
Anne Grapin-Botton, Ph.D. DanStem, Univeristy of Copenhagen	BCBC Investigator	Mechanisms of organ formation in the endoderm, Endocrine cell development, planar cell polarity, beta cell, architecture, polarity, Wnt pathway.
Dale Greiner, Ph.D. University of Massachusetts Medical School	BCBC Investigator	autoimmune diabetes, Transplantation tolerance, beta cell regeneration, humanized mice
Markus Grompe, M.D. Oregon Health & Science University	BCBC Investigator	metabolic liver diseases, molecular genetics of Fanconi Anemia, hepatic and pancreatic stem cells
Guoqiang Gu, Ph.D. Vanderbilt University	BCBC Investigator	Endocirne islet cell differentiation and functional maintenance, adult pancreatic progenitor during regeneration, cell marking and cell lineage
Manami Hara, D.D.S., Ph.D. The University of Chicago	BCBC Co-investigator	beta cell, islet, islet formation, pathology of the pancreas
David Harlan, MD University of Massachusetts	BCBC Investigator	Pathogenesis of type 1 diabetes mellitus, rejection organs/tissues transplanted with diabetes, exploring beta cell biology
Matthias Hebrok, PhD University of California, San Francisco	BCBC Investigator	Pancreas Islet Development
Harry Heimberg, Ph.D. Vrije Universiteit Brussels	BCBC Investigator	Biology of the pancreatic (pre)beta-cell.
Pedro Herrera, Ph.D. University of Geneva Faculty of Medicine	BCBC Investigator	pancreas development; beta cell development and generation; regeneration; reprogramming; cell tracing; transgenic mice
Klaus Kaestner, Ph.D. University of Pennsylvania	BCBC Investigator	Epigenomics of beta-cells; beta-cell proliferation; transcriptional regulation of pancreas development
Jeffrey Karp, B.Eng., Ph.D. Brigham and Women''s Hospital	BCBC Co-investigator	stem cell bioengineering, medical adhesives, diagnostic devices, medical devices, drug delivery, controlled release, sensors, nanotechnology, mesenchymal stem cell biology, cell trafficking, cell homing.
Mark Kay, M.D., Ph.D Stanford University	BCBC Investigator	gene transfer, gene therapy, viral vectors, non-viral vectors, small RNAs, MicroRNAs, RNA interference, hemophilia, diabetes, hepatitis
Gordon Keller, Ph.D. McEwen Centre for Regenerative Medicine/University Health Network	BCBC Investigator	embryonic hematopoietic and vascular systems
Seung Kim, M.D., Ph.D. Stanford University School of Medicine/HHMI	BCBC Investigator	Pancreas developmental biology, diabetes, islet biology, genetics, epigenetics
Eugene Kolker, Ph.D. Seattle Children''s Research Institute	BCBC Co-investigator	Computational Biology, Systems Biology, Data Analysis & Integration, Proteomics, Health Informatics
Rudy Leibel Columbia University	BCBC Co-investigator
Charles Lin, Ph.D Massachusetts General Hospital	BCBC Co-investigator	imaging, cell tracking, intravital microscopy
Ray MacDonald, Ph.D. University of Texas Southwestern Medical Center	BCBC Investigator	transcriptional control of organogenesis, pancreatic development, beta-cell birth, acinar-to-beta cell reprogramming
Ole Madsen, Ph.D. Hagedorn Research Institute	BCBC Investigator	antibody, cell surface, epitope, extracellular, cell lineage tracing, fluorescent cells, antibody tags, cell sorting, cell separation, cell culture, antibody mediated cell purification, protocol development.
Mark Magnuson, M.D. Vanderbilt University	BCBC Investigator	Pancreas Development, Mouse Models, Next Generation Sequencing, Cell Reprogramming
Melissa Mahoney, Ph.D. University of Colorado	BCBC Co-investigator
Doug Melton, Ph.D. Harvard / HHMI	BCBC Investigator	Microarray, Mouse/Human Stem Cell, Embryonic Development, Islet Cells, Pancreas Development
Stephen Miller, Ph.D. Northwestern University	BCBC Co-investigator	Immunoregulation, autoimmune disease, type 1 diabetes, mulitple sclerosis,experimental autoimmune encephalomyelitis, transplantation, tolerance, costimulatory molecule blockade
Anna Moore, Ph.D. Masachusetts General Hospital	BCBC Co-investigator	Molecular imaging, image-guided therapy, contrast agent, non-invasive monitoring of drug distribution
Chris Newgard, Ph.D. Duke University Medical Center	BCBC Investigator	metabolic regulatory mechanisms
Feroz Papa, M.D., Ph.D. University of California San Francisco	BCBC Investigator	apoptosis, stress signaling, endoplasmic reticulum, beta cells, insulin
Alvin Powers, M.D. Vanderbilt University	BCBC Investigator	diabetes, islet function, islet transplantation, vascularization
Philippe Ravassard, PhD CNRS – UMR 7225	BCBC Co-investigator	Pancreas development, beta cells, gene tranfer, lentiviral vectors
Bing Ren, Ph.D. University of California San Diego	BCBC Co-investigator	Epigenetics, Epigenome, ENCODE, gene regulation, embryonic stem cells
Maike Sander, M.D. University of California at San Diego	BCBC Investigator	Genetic control of pancreatic cell differentiation, using mouse and human embryonic stem cells as model systems.
Donald Scott, PhD University of pittsburgh	BCBC Co-investigator
Henrik Semb, Ph.D Copenhagen University	BCBC Investigator	pancreas development, human embryonic stem cells, beta cell differentiation, morphogenesis, epithelial-mesenchymal interactions, cell adhesion, cell migration, blood vessels
David Serreze, BS, MS, PhD The Jackson Laboratory	BCBC Co-investigator	type I diabetes, autoimmunity, mouse models, immune therapy
Leonard Shultz, Ph.D. The Jackson Laboratory	BCBC Investigator	Humanized mouse model for studying diabetes, bone development, autoimmunity
Michael Snyder, Ph.D Stanford University	BCBC Investigator	Genomics, Proteomics, Chip-Seq, RNA-Seq, Variation, Sequencing
Didier Stainier, Ph.D. Max Planck Institute for Heart and Lung Research	BCBC Investigator	The Stainier lab studies pancreatic beta-cell development and regeneration in zebrafish
Roland Stein, Ph.D. Vanderbilt University	BCBC Investigator	Control of islet beta cell development and function
Andrew Stewart, M.D. Mount Sinai School of Medicine	BCBC Investigator	Cell Cycle Control Human Beta Cells
Christian Stoeckert, Ph.D. University of Pennsylvania	BCBC Investigator	Bioinformatics, networks, gene regulation
Doris Stoffers, M.D., Ph.D. Perelman School of Medicine at the University of Pennsylvania	BCBC Investigator	diabetes, insulin, beta cell, pancreas development, transcriptional regulation, signal transduction
Philip Streeter, Ph.D. Oregon Health & Science University	BCBC Investigator	Tissue engineering, tissue repair, lung progenitor cells, pancreatic cancer
Lori Sussel, Ph.D. Columbia University	BCBC Investigator	Genetic Differentiation of Endocrine Pancreatic Cells
Rupangi Vasavada, Ph.D. Icahn School of Medicine at Mount Sinai	BCBC Co-investigator	Pancreatic beta cell, growth factors, lactogens, parathyroid-hormone-related peptide, apoptosis, proliferation, regeneration, signaling, diabetes, islet transplants, human beta cell.
James Wells, PhD Cincinnati Children''s Hospital Medical Center	BCBC Co-investigator	Endoderm organogenesis, human pluripotent stem cells, endocrine cell development, metabolic disease, Diabetes
Karl Willert, Ph.D University of California, San Diego	BCBC Investigator	Cell signaling, Cellular Microarray Technology, Extracellular Microenvironment, Human Pluripotent Stem Cells, Microarray, Stem Cells, Wnt, Wnt Signaling
Chris Wright, D. Phil. Vanderbilt University	BCBC Investigator	Molecular embryology, vertebrate embryogenesis, transcription factors, intercellular signaling, stem cells
Mervin Yoder, M.D. Indiana University	BCBC Investigator	stem cells, B1 B cell, progenitor cells, angiogenesis
Peter Zandstra, PhD University of Toronto	BCBC Investigator	Stem Cell Bioengineering, Regenerative Medicine, Cellular Engineering, Biprocess Engineering, Population Dynamics, Signaling Dynamics, Pluripotent (P) Stem Cells, Embryonic (E) Stem Cells, Cellular Systems Biology
Yi Zhang, Ph.D. Harvard Medical School & Boston Children''s Hospital	BCBC Investigator	Epigenetics, reprogramming, stem cells, iPS cells, chromatin, transcription, islet transplantation, transdifferentiation
Qiao Zhou, Ph.D. Harvard University	BCBC Investigator	regeneration, beta cells, in vivo reprogramming, diabetes