http://www.betacell.org/news/ News and Events of the Beta Cell Biology Consortium Thu, 12 Jan 2012 19:25:23 +0000 en-us Copyright 2012, Beta Cell Biology Consortium http://www.betacell.org/news/index.php?view=143 http://www.betacell.org/news/index.php?view=143 Thu, 01 Jan 1970 00:00:00 +0000 http://www.betacell.org/news/index.php?view=146 http://www.betacell.org/news/index.php?view=146 Thu, 01 Jan 1970 00:00:00 +0000 http://www.betacell.org/news/index.php?view=145 http://www.betacell.org/news/index.php?view=145 Thu, 01 Jan 1970 00:00:00 +0000 212-479-7663 e. ahwa@jdrf.org ADMINISTRATIVE Bridget Donnelly Grants Coordinator p. 212-479-7614 e. Bdonnelly@jdrf.org http://www.betacell.org/news/index.php?view=142 http://www.betacell.org/news/index.php?view=142 Thu, 01 Jan 1970 00:00:00 +0000 Payments can be made by bank transfer or credit card. The rate will increase after September 1. NEW: Late breaking abstracts may be submitted until September 30th. Topics Transcriptional Regulation of Beta Cell Development Postnatal Maturation of Beta Cells Adaptation of Beta Cells to Pregnancy Beta Cell Dysfunction in Type 2 Diabetes Beta Cell Destruction in Type 1 Diabetes Beta Cell Regeneration by Beta Cell Proliferation? Beta Cell Regeneration by Neogenesis? Workshops Omics in Beta Cell Research Imaging Beta Cells Beta Cell Identity Epigenetícs in Beta Cell Biology Mechanisms in Autoimmunity Stem cells to Beta Cells Please refer to ttp://bmi.ku.dk/beta_cell_workshop_2011 for any questions about the workshop.  The BCBC CC has posted this announcement but is not involved in the workshop planning. http://www.betacell.org/news/index.php?view=140 http://www.betacell.org/news/index.php?view=140 Thu, 01 Jan 1970 00:00:00 +0000 We had “locked down” this ability so that we could make strong guarantees about the integrity of the BCBC Resource Collections: it was a simple way to make sure that important metadata was not lost after the Resource had been reviewed and approved. But, understandably, the simple solution was not the ideal solution. Therefore, we have created a resource-archiving system that allows the site administrators to view the entire change history for any Resource. With that system in place we feel much better about restoring your ability to edit contributed Resources on an ongoing basis. Simple Keyword Search of Beta Cell Genomics Data As of version 4.5 you may perform a simple keyword search of Genomics.org from the front page of Betacell.org, to find genes and studies. You can then use the Beta Cell Genomics’s search strategy tools to refine your search. Beta Cell Genomics Enhancements Genome browser tracks relative to study Open chromatin in human pancreatic islets (FAIRE-seq) have been updated and data from a related sample have been added. We have expanded all searches taking a gene identifier to include any of: Entrez Gene ID, symbol, MGI or GeneCards ID. We have made gene-lists available also for BCBC-restricted studies, upon login. Events Dashboard-widget There is a new widget on the Dashboard of Investigators and Affiliates that list all BCBC events that the member has attended or to which they have been invited. From here you can view Details of a past event, and Register or Review Registration for an upcoming event Other When you register for a BCBC event using Betacell.org’s Event Management system, you may specify which of the event’s meals you are planning to attend, if you are a Day Guest. We have improved how image thumbnails are rendered. New Resources Adenovirus OE.E. coli.rtTA.CMV - public access OE.Human.CDK6.Tetracycline Responsive Element (TRE) - public access OE.Human.NEUROG3.CMV - BCBC access OE.Human.NEUROG3.CMV - BCBC access OE.Human.Neurogenin 3.CMV - BCBC access OE.Human.NKX6-1.CMV - BCBC access OE.Human.PDX1.CMV - BCBC access OE.Mouse.Arx.CMV - BCBC access OE.Mouse.Neurog3.CMV - BCBC access OE.Mouse.Pax4.CMV - BCBC access OE.Mouse.Pdx1.CMV - BCBC access OE.Unclassified.eGFP.Human Insulin - BCBC access Genomics Studies Pancreatic beta cell identity is maintained by DNA methylation-mediated repression of Arx (Dhawan et al., Developmental Cell, 2011). The goal of this study is to test the hypothesis that key determinants of the alpha cell lineage are methylated and repressed to maintain beta cell lineage stability, and these determinants are derepressed in the beta cells deficient in DNA methylation. We have added a track to the genome browser showing results from this study. Public access. Transcriptional Profiling of Ngn3-dependent endocrine progenitors and pre-beta cells BCBC access, Gu lab. Gene expression profiling of hESC derived eGFP-SOX17+ endoderm cells (Wang et al., Cell stem cell, 2011). The goal of this study is to identify a cell surface marker signature for human endodermal cells. We ahve added new marker characteristics derived from this study.Public access Functional analysis of the Nkx2.2 SD domain: gene expression profiling of E16.5 Nkx2.2 SD mutant pancreata versus wild-type littermate pancreata BCBC access, Sussel lab. Gene expression profiling of wild-type, Nkx2.2 null, NeuroD null and Nkx2.2/NeuroD double KO E13.5 pancreata BCBC access, Sussel lab. Miscellaneous 10 questions about your dataset - Public access Analyzing RNA-Seq data as aligned reads, expression profiles, and networks - BCBC access Key Tools for ChIP-seq Data Analysis and Comparison - BCBC access RNA-seq and ChIP-seq data management - BCBC access Mouse ES Cell Lines Ptf1a.tdTOM - BCBC access Rosa26(BiTetO-Ngn3/Mafa) - BCBC access Rosa26(mIre1.IG.Cherry) - BCBC access Rosa26(mIre1.WT.Cherry) - BCBC access Mouse Strains Rosa26tm1.1(mlre1.IG.Cherry)Fpa - BCBC access Rosa26tm1.5(Nepn.Cherry)Mgn- BCBC access Rosa26tm1(mlre1.WT.Cherry)Fpa - BCBC access Rosa26tm2.2(R26-228-IBRE4-TA-Cerulean)Hri - BCBC access http://www.betacell.org/news/index.php?view=141 http://www.betacell.org/news/index.php?view=141 Thu, 01 Jan 1970 00:00:00 +0000 - Massachusetts Institute of Technology Establishing immunological tolerance to transplanted pancreatic beta-cellsDavid Serreze, Ph.D. - The Jackson LaboratoryDale Greiner, Ph.D. - University of Massachusetts Medical SchoolStephen Miller, Ph.D. - Northwestern University Investigation of New Permissive Environments for Beta Cell EngraftmentJeffrey Karp Ph.D. - Brigham and Women''s Hospital MedicineCharles Lin Ph.D. - Massachusetts General HospitalMaike Sander Ph.D. - University of California at San Diego 3-D growth of pancreatic beta cells from human pluripotent stem cellsJames Wells, Ph.D. - Cincinnati Children Division of Developmental BiologyMaike Sander Ph.D. - University of California at San Diego Enhancer-based beta-cell programming strategiesMaike Sander Ph.D. - University of California at San DiegoKlaus Kaestner Ph.D. - University of Pennsylvania Department of GeneticsBing Ren Ph.D. - University of California San Diego Non-neoplastic replication to expand functional beta-cell massKlaus Kaestner Ph.D. - University of Pennsylvania Department of GeneticsBenjamin Glaser Ph.D. - Hadassah-Hebrew University Medical Center Proteomic analysis of mesenchymal factorsMatthias Hebrok Ph.D. - University of California, San FranciscoEugene Kolker Ph.D. - Seattle Children''s Research Institute Theragnostic nanoparticles for therapy and imagin gin type-1 diabetesAnna Moore Ph.D. - Masachusetts General Hospital